The role of intestinal microflora in the activation of benzidine and benzidine congener based dyes
Conference
·
· Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA)
OSTI ID:7067634
- National Center for Toxicological Research, Jefferson, AR (USA)
Benzidine-based dyes are widely used in the dye manufacturing, textile dyeing, color paper printing and leather industries. Some benzidine based dyes have been shown to be carcinogenic due to their biotransformation in the liver or in the gastrointestinal tract to benzidine, a long recognized human urinary bladder carcinogen. Occupational exposure to workers can be through skin absorption, inhalation and ingestion of the benzidine based dyes. Previous studies of benzidine based dye metabolism have shown that enzymatic reduction of the azo group, yielding benzidine is an essential step in the activation of these compounds to genotoxic species. Azo reduction activity is present in both the liver and gastrointestinal tract and little is known whether the first step in the toxification process of benzidine based dyes occurs at either site. They are investigating the capacity of intestinal microflora to metabolize benzidine-based dyes and determine their overall importance in the activation of this class of industrially important chemicals.
- OSTI ID:
- 7067634
- Report Number(s):
- CONF-8909234--
- Conference Information:
- Journal Name: Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA) Journal Volume: 28:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
AMINES
AROMATICS
BENZIDINE
DATA
DYES
EXPERIMENTAL DATA
INFORMATION
INTESTINAL ABSORPTION
MATERIALS
METABOLIC ACTIVATION
MICROORGANISMS
NUMERICAL DATA
ORGANIC COMPOUNDS
TOXIC MATERIALS
UPTAKE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
AMINES
AROMATICS
BENZIDINE
DATA
DYES
EXPERIMENTAL DATA
INFORMATION
INTESTINAL ABSORPTION
MATERIALS
METABOLIC ACTIVATION
MICROORGANISMS
NUMERICAL DATA
ORGANIC COMPOUNDS
TOXIC MATERIALS
UPTAKE