Angiotensin-converting enzyme inhibition and regional cerebral blood flow in acute stroke

Journal Article · Wed Nov 01 00:00:00 EST 1989 · Journal of Cardiovascular Pharmacology; (USA)

DOI:https://doi.org/10.1097/00005344-198911000-00008· OSTI ID:7066831

Waldemar, G; Vorstrup, S; Andersen, A R; Pedersen, H; Paulson, O B ^[1]

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1. Rigshospitalet, Copenhagen (Denmark)

The effect of the angiotensin-converting enzyme (ACE) inhibitor captopril on regional cerebral blood flow (rCBF) was studied in 12 patients within 5 days after their first acute stroke. rCBF was studied by xenon-133 inhalation and single-photon emission computed tomography (SPECT) scan before and 1 h after oral administration of 25 mg captopril. No increase in rCBF was observed in any of the 12 patients included in the study. In only one patient was there a slight redistribution of blood flow in favor of the low-flow area, but the absolute flow value did not increase. Captopril did not cause any significant change in mean hemispheric blood flow, mean arterial blood pressure (MAP), or end-expiratory CO2 fraction (FECO2). The assumption that ACE inhibition might increase cerebral blood flow in the periinfarct zone and preserve some still viable brain tissue could not be verified in the present study.

• OSTI ID: 7066831
• Journal Information: Journal of Cardiovascular Pharmacology; (USA), Vol. 14:5; ISSN 0160-2446
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
CEREBRAL CORTEX
BLOOD FLOW
ENZYME INHIBITORS
BIOLOGICAL EFFECTS
ANTIHYPERTENSIVE AGENTS
BLOOD PRESSURE
PATIENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TRACER TECHNIQUES
XENON 133
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
TOMOGRAPHY
XENON ISOTOPES
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