Changes in cerebral blood flow and recovery from acute stroke

Journal Article · Sat Mar 01 04:00:00 EST 1986 · Stroke; (United States)

DOI:https://doi.org/10.1161/01.STR.17.2.173· OSTI ID:5617811

Burke, A M; Younkin, D; Gordon, J; Goldberg, H; Graham, T; Kushner, M; Obrist, W; Jaggi, J; Rosen, M; Reivich, M

We prospectively studied 14 patients with acute cerebral infarctions using serial /sup 133/Xenon inhalation cerebral determination (/sup 133/Xe-rCBF), scored neurological examinations, and neuropsychological testing. All patients underwent the same battery of tests at 3 days, 1 week, 2 weeks, and 4 weeks after cerebral infarction to determine the prognostic value of early rCBF studies and the chronological relationship of changes in rCBF to clinical status. Baseline rCBF within 3 days of symptoms of acute stroke did not correlate with clinical neurological outcome (r = -0.17, p less than 0.30; r = -0.18, p less than 0.28, for the two indices of rCBF used). Among the 11 patients demonstrating neurological recovery, 7 improved at 1 week, significantly before increases in rCBF (p less than 0.05). We conclude that early baseline rCBF does not predict clinical outcome in patients with acute cerebral infarctions and that return of neurological function precedes rather than follows increases in rCBF.

• Research Organization: Michael Reese Hospital and Medical Center, Chicago, IL
• OSTI ID: 5617811
• Journal Information: Stroke; (United States), Journal Name: Stroke; (United States) Vol. 2; ISSN SJCCA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
PATIENTS
RADIOISOTOPES
RECOVERY
VASCULAR DISEASES
XENON 133
XENON ISOTOPES