Induction of chromosomal aberrations in bone marrow cells of asbestotic rats

Journal Article · Wed Apr 01 04:00:00 EST 1992 · Environmental Research; (United States)

DOI:https://doi.org/10.1016/S0013-9351(05)80077-5· OSTI ID:7066319

Fatma, N; Khan, S G; Aslam, M; Rahman, Q ^[1]

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1. Industrial Toxicology Research Centre, Lucknow (India)

In the present study, cytogenetic effects of Indian chrysotile asbestos in rat bone marrow cells after 290 days of intratracheal inoculation, when it develops massive pulmonary fibrosis, were investigated. The pulmonary fibrosis was confirmed by both histopathological studies and increased collagen content in the lung of the treated animals. In the asbestotic rats a significant increase in chromosomal aberrations was recorded and a decrease in mitotic index of bone marrow cells. The types of chromosomal aberrations in these cells were chromatid gaps and breaks. The results indicate the significant cytogenetic changes in the bone marrow cells of asbestotic rats and also suggest that these changes directly or indirectly may be one of the biological events involved in eliciting the asbestos-mediated toxic responses.

• OSTI ID: 7066319
• Journal Information: Environmental Research; (United States), Journal Name: Environmental Research; (United States) Vol. 57:2; ISSN ENVRA; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ASBESTOS
BIOLOGICAL EFFECTS
BODY
BONE MARROW CELLS
CHROMOSOMAL ABERRATIONS
COLLAGEN
CONNECTIVE TISSUE CELLS
FIBROSIS
GENETIC EFFECTS
LUNGS
MAMMALS
MITOTIC INDEX
MUTATIONS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
RATS
RESPIRATORY SYSTEM
RODENTS
SCLEROPROTEINS
SOMATIC CELLS
VERTEBRATES