Studies on the role of iron in the reversal of zinc, cadmium, vanadium, nickel, and cobalt toxicities in boiler pullets

Thesis/Dissertation · Wed Jan 01 04:00:00 EST 1986

OSTI ID:7065667

Blalock, T L

Excess dietary iron reduced the toxicity of cadmium (Cd), cobalt (Co), nickel (Ni) and vanadium (V) in chicks. In order to gain further insight into this phenomenon, the toxicity of these elements was examined under conditions of dietary iron deficiency, ca. 10 ppm, and excess, ca. 1010 ppm. Graded levels of Cd, Co, Ni, V and also of zinc (Zn) were added to achieve toxicities of these heavy metals. In every case the iron-supplemented chicks were less susceptible to the every case the iron-supplemented chicks were less susceptible to the toxicities of these elements than were those chicks receiving the iron-deficient diet. The results of these studies revealed that Fe alters the metabolism of Zn, Cd, V, Ni and Co in livers and kidneys of chicks. The data further show that Zn, Cd, and Co alter Fe metabolism in chick livers and kidneys. Additionally, hemoglobin concentration was altered by Zn, Cd, and V, as well as Fe, in chicks. The locus of these interactions was more clearly defined using the radioactive tracers /sup 109/Cd, /sup 60/Co, /sup 63/Ni, /sup 48/V, and /sup 65/Zn. Iron deficiency increased absorption of Co and Ni, reduced liver retention of Cd, and Zn without affecting absorption and increased blood and liver levels of V, possibly as a result of decreased bone uptake. The alteration of liver metabolism of Cd and Zn in iron deficiency was investigated using column chromatography and atomic absorption spectrophotometry. Adequate dietary iron appears to act synergistically with Cd and Zn to induce metallothionein in the liver. Increased dietary Fe was observed to result in an increased liver influx of Zn and Cd. It is possible that iron acts in this manner to induce metallothionein synthesis.

• Research Organization: North Carolina State Univ., Raleigh (USA)
• OSTI ID: 7065667
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTROSCOPY
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BIRDS
CADMIUM 109
CADMIUM ISOTOPES
CARBOXYLIC ACIDS
CHICKENS
CHROMATOGRAPHY
COBALT 60
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FOWL
GLOBIN
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRON
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
METABOLISM
METALLOPROTEINS
METALLOTHIONEIN
METALS
MINUTES LIVING RADIOISOTOPES
NICKEL 63
NICKEL ISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RADIOISOTOPES
SEPARATION PROCESSES
SPECTROSCOPY
SYNTHESIS
TOXICITY
TRACER TECHNIQUES
TRANSITION ELEMENTS
VANADIUM 48
VANADIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
ZINC 65
ZINC ISOTOPES