Mechanisms of alleviation of Zn, Cd, V, Ni and Co toxicities by dietary iron

Conference · Fri Feb 28 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5430367

Blalock, T L; Hill, C H

Previous studies from this laboratory have demonstrated that supplemental dietary iron (Fe), i.e. 1000 ppm, ameliorated zinc (Zn), cadmium (Cd), vanadium (V), nickel (Ni), and cobalt (Co) toxicities in chicks. Investigations into the mechanisms of this detoxification have been conducted. Chicks were fed diets containing 10, 110 or 1010 ppm iron along with 0 or 4000 ppm Zn, 0 or 40 ppm Cd, 0 or 40 ppm V, 0 or 400 ppm Ni or 0 or 400 ppm Co. In every case the Fe supplemented chicks were less susceptible to the toxicities of these elements as measured by reduction in growth rate than were the iron deficient chicks. The effects of iron on the absorption and distribution of these elements were measured by using radioactive isotopes of the elements. The absorption of Co and Ni was significantly reduced when the diet was adequate in iron. Significantly more vanadium was found in the bone of the iron supplemented chicks and less in liver and kidneys. Significantly more Cd and Zn was found in the liver and less in the blood when dietary iron was adequate. Gel filtration revealed that less Cd and Zn was found on the peak eluting in the volume of metallothionein in those chicks receiving the iron deficient diet. These results suggest the possibility that iron may be essential for the formation of metallothionein. The results also indicate that the protective effect of iron on these toxicities in brought about by several mechanisms.

• Research Organization: North Carolina State Univ., Raleigh
• OSTI ID: 5430367
• Report Number(s): CONF-8604222-
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:3; ISSN FEPRA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL GROWTH
ANIMALS
BIOLOGICAL EFFECTS
BIRDS
CADMIUM
CHICKENS
COBALT
DIET
ELEMENTS
FOWL
GROWTH
IRON
ISOTOPE APPLICATIONS
ISOTOPES
METALS
NICKEL
NUTRITIONAL DEFICIENCY
RADIOISOTOPES
TOXICITY
TRACER TECHNIQUES
TRANSITION ELEMENTS
VANADIUM
VERTEBRATES
ZINC