Sister chromatid exchange induced by short-lived monoadducts produced by the bifunctional agents mitomycin C and 8-methoxypsoralen. [CHO cells]
Journal Article
·
· Environ. Mutagen.; (United States)
To see if DNA crosslinks are involved in the induction of sister chromated exchange (SCE), Chinese hamster ovary cells were exposed to two bifunctional alkylating agents,mitomycin C and 8-methoxypsoralen, and their monofunctional derivatives, decarbamoyl mitomycin C and angelicin. The data indicates that monoadducts, rather than crosslinks, are responsible for SCE formation. Furthermore, all agents but angelicin produced short-lived lesions that led to SCEs in the first period of DNA replication after treatment (twin SCEs). In contrast, angelicin, like methyl methanesulfonate and N-acetoxyacetylaminofluorene, produced lesions that lasted more than one cycle, indicating that several different types of DNA lesions are capable of SCE induction.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 7065457
- Journal Information:
- Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 4:3; ISSN ENMUD
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Sister chromatid exchange, DNA repair, and single-gene mutation
Journal Article
·
Sat Dec 31 23:00:00 EST 1983
· Environ. Mutagen.; (United States)
·
OSTI ID:6722382
Segregation of DNA polynucleotide strands into sister chromatids and the use of endoreduplicated cells to track sister chromatid exchanges induced by crosslinks, alkylations, or x-ray damage
Journal Article
·
Tue Jun 11 00:00:00 EDT 1996
· Proceedings of the National Academy of Sciences of the United States of America
·
OSTI ID:457013
Sister chromatid exchange, DNA repair, and single-gene mutation
Conference
·
Sun Apr 12 23:00:00 EST 1981
·
OSTI ID:6794313
Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKOXY RADICALS
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTICOAGULANTS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOASSAY
BIOLOGICAL EFFECTS
BODY
CHEMICAL REACTIONS
CHROMOSOMAL ABERRATIONS
COUMARINS
CROSS-LINKING
DAMAGE
DNA
DRUGS
FEMALE GENITALS
GONADS
HAMSTERS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MAMMALS
METABOLITES
METHOXY RADICALS
MITOMYCIN
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OVARIES
POLYMERIZATION
PSORALEN
RADICALS
RODENTS
SISTER CHROMATID EXCHANGES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKOXY RADICALS
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTICOAGULANTS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOASSAY
BIOLOGICAL EFFECTS
BODY
CHEMICAL REACTIONS
CHROMOSOMAL ABERRATIONS
COUMARINS
CROSS-LINKING
DAMAGE
DNA
DRUGS
FEMALE GENITALS
GONADS
HAMSTERS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MAMMALS
METABOLITES
METHOXY RADICALS
MITOMYCIN
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OVARIES
POLYMERIZATION
PSORALEN
RADICALS
RODENTS
SISTER CHROMATID EXCHANGES
VERTEBRATES