3-Fluoro-Deoxyglucose for the assessment of cerebral perfusion and glucose transport - Indications for extracranial-intracranial arterial bypass and followup studies
3-Fluor-Deoxyglucose (3FDG) is a glucose-analogue which is transported across the blood-brain-barrier by the same carrier as glucose but is only phoshorylated to a minor part. By a newly developed model, it became possible to estimate both cerebral perfusion and glucose transport in a single examination, determining the Michaelis-Menten-constant K/sub M/ and the maximal velocity v/sub m/. Normal values were determined as follows: gray matter perfusion 88+-8 ml/ 100g min; v/sub m/ was 2.46 ..mu..mol/g min; K/sub M/ was 6.42 ..mu..mol/g. This method was applied successfully in a series of 15 patients with cerebral ischemia to select suitable candidates for extacranial-intracranial (EC-IC) arterial bypass surgery and to follow them up to 15 months postop. In patients with minor strokes and transient ischemic attacks (TIA), areas which appeared normal in conventional CT presented with reduced perfusion values (down to 67 ml/ 100 g min) and either normal or reduced v/sub m/ (down to 0.8 ..mu..mol/g min). These patients were thought optimal candidates for EC-IC bypass in order to improve the misery perfusion rate.
- Research Organization:
- Univ. of Essen Medical Center, Essen, Herzzentrum NRW, Bad Oeynhausen
- OSTI ID:
- 7064654
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANTIMETABOLITES
ARTERIES
BIOCHEMICAL REACTION KINETICS
BLOOD FLOW
BLOOD VESSELS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRAL ARTERIES
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
FLUORODEOXYGLUCOSE
GLUCOSE
HEXOSES
ISCHEMIA
KINETICS
MEDICINE
MEMBRANE TRANSPORT
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PATIENTS
REACTION KINETICS
SACCHARIDES
SURGERY
TOMOGRAPHY
UPTAKE
VASCULAR DISEASES
VELOCITY