A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human. alpha. /. delta. T-cell receptor locus

Journal Article · Thu Feb 01 04:00:00 EST 1990 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.87.3.960· OSTI ID:7064235

Hanson, R D; Hohn, P A; Ley, T J ^[1]; Popescu, N C ^[2]

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1. Jewish Hospital at Washington Univ. Medical Center, St. Louis, MO (USA)
2. National Cancer Institute, Bethesda, MD (USA)

The chymotrypsin-like family of serine protease genes includes several members that are expressed exclusively in subsets of hematopoietic cells. For example, human neutrophil elastase and cathepsin G are expressed only in myelomonocytic precursors, and cytotoxic-T-cell serine proteases are found only in cytotoxic lymphocytes. The authors have used a cathepsin G cDNA probe to clone two cathepsin G-like genes (designated CGL-1 and CGL-2) from a human genomic library. They have determined that CGL-1 is identical to a previously identified gene (known as CCPI, CTLA I, or cytotoxic serine protease B) that is expressed only in activated cytotoxic T lymphocytes. They show here that cathepsin G, CGL-1, and CGL-2 are linked on an {approx}50-kilobase locus found on human chromosome 14 at band q11.2. This gene cluster maps to the same chromosomal band as the {alpha} and {delta} T-cell receptor genes; this region is involved in most chromosomal translocations and inversions that are specifically associated with T-cell malignancies.

• OSTI ID: 7064235
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 87:3; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CATHEPSINS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CHYMOTRYPSIN
CLONING
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
DNA
DNA HYBRIDIZATION
DNA-CLONING
ENZYMES
GENES
GENETIC MAPPING
HETEROCHROMOSOMES
HYBRIDIZATION
HYDROGEN COMPOUNDS
HYDROLASES
ISOTOPES
LEUKOCYTES
LIGHT NUCLEI
LYMPHOCYTES
MAPPING
MATERIALS
MUTATIONS
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PEPTIDE HYDROLASES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIOISOTOPES
RECOMBINANT DNA
SERINE PROTEINASES
SH-PROTEINASES
SOMATIC CELLS
TRITIUM COMPOUNDS