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Title: The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily

Abstract

Human granzyme A (HFSP, Hanukah factor serine protease; CTLA3, cytotoxic T-lymphocyte-associated serine esterase-3), a homodimeric, trypsin-like serine protease of 60 kDa found in granules of cytolytic T cells and natural killer cells, is implicated in lymphocyte-mediated target cell lysis. It contributes to DNA fragmentation in perforin (PRF1)-lysed target cells through an unknown mechanism. The authors have isolated a cosmid clone for the functional gene of human granzyme A and established its complete exon-intron map of 10 kb. Using an 11-kb subfragment of the cloned genomic DNA as a probe, they have identified the chromosomal position of human granzyme A on 5q11-q12. Thus, the human granzyme A gene falls into a region of homology between human chromosome 5 and mouse chromosome 13, band D, where the mouse granzyme A gene has been located previously. The granzyme A gene is not linked to known members of the large superfamily of serine proteases. 20 refs., 2 figs.

Authors:
;  [1]; ; ;  [2]
  1. (Institut fuer angewandte Tumorvirologie, Heidelberg (Germany))
  2. (Max-Planck-Institut fuer Psychiatrie, Planegg-Martinsried (Germany))
Publication Date:
OSTI Identifier:
6975050
Resource Type:
Journal Article
Resource Relation:
Journal Name: Genomics; (United States); Journal Volume: 18:2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; HUMAN CHROMOSOME 5; GENETIC MAPPING; SERINE PROTEINASES; GENES; CELL KILLING; DNA SEQUENCING; DNA-CLONING; CHROMOSOMES; CLONING; DNA HYBRIDIZATION; ENZYMES; HUMAN CHROMOSOMES; HYBRIDIZATION; HYDROLASES; MAPPING; ORGANIC COMPOUNDS; PEPTIDE HYDROLASES; PROTEINS; STRUCTURAL CHEMICAL ANALYSIS; 550400* - Genetics

Citation Formats

Fink, T.M., Lichter, P., Wekerle, H., Zimmer, M., and Jenne, D.E. The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily. United States: N. p., 1993. Web. doi:10.1006/geno.1993.1483.
Fink, T.M., Lichter, P., Wekerle, H., Zimmer, M., & Jenne, D.E. The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily. United States. doi:10.1006/geno.1993.1483.
Fink, T.M., Lichter, P., Wekerle, H., Zimmer, M., and Jenne, D.E. Mon . "The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily". United States. doi:10.1006/geno.1993.1483.
@article{osti_6975050,
title = {The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily},
author = {Fink, T.M. and Lichter, P. and Wekerle, H. and Zimmer, M. and Jenne, D.E.},
abstractNote = {Human granzyme A (HFSP, Hanukah factor serine protease; CTLA3, cytotoxic T-lymphocyte-associated serine esterase-3), a homodimeric, trypsin-like serine protease of 60 kDa found in granules of cytolytic T cells and natural killer cells, is implicated in lymphocyte-mediated target cell lysis. It contributes to DNA fragmentation in perforin (PRF1)-lysed target cells through an unknown mechanism. The authors have isolated a cosmid clone for the functional gene of human granzyme A and established its complete exon-intron map of 10 kb. Using an 11-kb subfragment of the cloned genomic DNA as a probe, they have identified the chromosomal position of human granzyme A on 5q11-q12. Thus, the human granzyme A gene falls into a region of homology between human chromosome 5 and mouse chromosome 13, band D, where the mouse granzyme A gene has been located previously. The granzyme A gene is not linked to known members of the large superfamily of serine proteases. 20 refs., 2 figs.},
doi = {10.1006/geno.1993.1483},
journal = {Genomics; (United States)},
number = ,
volume = 18:2,
place = {United States},
year = {Mon Nov 01 00:00:00 EST 1993},
month = {Mon Nov 01 00:00:00 EST 1993}
}