The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily
- Institut fuer angewandte Tumorvirologie, Heidelberg (Germany)
- Max-Planck-Institut fuer Psychiatrie, Planegg-Martinsried (Germany)
Human granzyme A (HFSP, Hanukah factor serine protease; CTLA3, cytotoxic T-lymphocyte-associated serine esterase-3), a homodimeric, trypsin-like serine protease of 60 kDa found in granules of cytolytic T cells and natural killer cells, is implicated in lymphocyte-mediated target cell lysis. It contributes to DNA fragmentation in perforin (PRF1)-lysed target cells through an unknown mechanism. The authors have isolated a cosmid clone for the functional gene of human granzyme A and established its complete exon-intron map of 10 kb. Using an 11-kb subfragment of the cloned genomic DNA as a probe, they have identified the chromosomal position of human granzyme A on 5q11-q12. Thus, the human granzyme A gene falls into a region of homology between human chromosome 5 and mouse chromosome 13, band D, where the mouse granzyme A gene has been located previously. The granzyme A gene is not linked to known members of the large superfamily of serine proteases. 20 refs., 2 figs.
- OSTI ID:
- 6975050
- Journal Information:
- Genomics; (United States), Vol. 18:2; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HUMAN CHROMOSOME 5
GENETIC MAPPING
SERINE PROTEINASES
GENES
CELL KILLING
DNA SEQUENCING
DNA-CLONING
CHROMOSOMES
CLONING
DNA HYBRIDIZATION
ENZYMES
HUMAN CHROMOSOMES
HYBRIDIZATION
HYDROLASES
MAPPING
ORGANIC COMPOUNDS
PEPTIDE HYDROLASES
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
550400* - Genetics