Effect of chronic renal failure on high-density lipoprotein kinetics

Journal Article · Tue May 01 04:00:00 EDT 1990 · Kidney International; (USA)

DOI:https://doi.org/10.1038/ki.1990.114· OSTI ID:7063734

Fuh, M M; Lee, C M; Jeng, C Y; Shen, D C; Shieh, S M; Reaven, G M; Chen, Y D ^[1]

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1. Stanford Univ. School of Medicine, CA (USA)

Plasma lipid and lipoprotein concentration and high density lipoprotein (HDL) kinetics were determined in control subjects and patients with chronic renal failure (CRF). Results demonstrated that plasma triglyceride (TG) concentration was significantly higher (P less than 0.001) in patients with CRF, associated with a significant increase in plasma VLDL-cholesterol (P less than 0.002) and a significant decrease (P less than 0.05) in plasma HDL-cholesterol concentration. The rate of removal of {sup 125}I-apoAI/HDL from plasma was slower (P less than 0.001) in the patients with CRF, resulting in an increase in the residence time of {sup 125}I-apoAI/HDL (P less than 0.001) and a decrease in the fractional catabolic rate (P less than 0.001). Since plasma apoAI concentration was lower in patients with CRF, total apoAI/HDL synthetic rate was also significantly (P less than 0.05) decreased. These data provide support for the view that low plasma HDL-cholesterol concentrations in patients with CRF are related to decreases in the synthetic rate of apoAI/HDL.

• OSTI ID: 7063734
• Journal Information: Kidney International; (USA), Journal Name: Kidney International; (USA) Vol. 37:5; ISSN 0085-2538; ISSN KDYIA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOSYNTHESIS
BODY
CARBOXYLESTERASES
CHOLESTEROL
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
ESTERASES
ESTERS
HYDROLASES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LIPASES
LIPIDS
LIPOPROTEINS
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PATIENTS
PRIMATES
PROTEINS
RADIOISOTOPES
STEROIDS
STEROLS
SYNTHESIS
TRACER TECHNIQUES
TRIGLYCERIDES
UROGENITAL SYSTEM DISEASES
VERTEBRATES