Effect of prazosin treatment on HDL kinetics in patients with hypertension

Journal Article · Mon Oct 01 04:00:00 EDT 1990 · American Journal of Hypertension; (USA)

OSTI ID:6068867

Sheu, W H; Swislocki, A L; Hoffman, B B; Reaven, G M; Chen, Y D ^[1]

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1. Stanford Univ. School of Medicine, CA (USA)

The effect of prazosin treatment on blood pressure, plasma HDL-cholesterol concentration, and apoprotein-AI/HDL (apoAI/HDL) kinetics was studied in 11 patients with mild hypertension. Blood pressure (mean +/- SEM) fell from 143 +/- 1/96 +/- 1 to 134 +/- 1/86 +/- 1 mm Hg after 4 to 5 months of prazosin treatment (P less than .001), associated with an increase in plasma HDL-cholesterol concentration from 38 +/- 2 to 46 +/- 2 mg/dL (P less than .001). Both the fractional catabolic rate (FCR) and total synthetic rate of apoAI/HDL, which were higher than previous reported values for normal individuals, decreased from 0.36 +/- 0.02 to 0.30 +/- 0.02 L/day and 17.4 +/- 1.1 to 13.8 +/- 1.1 mg/kg/min, respectively. These changes were statistically significant, and the post-treatment values for both variables were now within the normal range. When the decay curve was further analyzed by nonlinear curve fitting, it was shown that the return to normal of the FCR of apoAI/HDL in patients treated with prazosin was accounted for by the decrease of the decay constants of the second (p(2)) and third (p(3)) components of the 125I-AI/HDL disappearance curve. In conclusion, abnormalities in HDL concentration and HDL kinetics exist in patients with very mild hypertension. These defects were significantly improved with prazosin treatment, and this may render the compound of particular clinical benefit in the treatment of patients with mild hypertension.

• OSTI ID: 6068867
• Journal Information: American Journal of Hypertension; (USA), Journal Name: American Journal of Hypertension; (USA) Vol. 3:10; ISSN 0895-7061; ISSN AJHYE
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
APOLIPOPROTEINS
BETA DECAY RADIOISOTOPES
BIOSYNTHESIS
BLOOD PRESSURE
CARDIOVASCULAR DISEASES
CHEMOTHERAPY
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HYPERTENSION
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIPIDS
LIPOPROTEINS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATIENTS
PROTEINS
RADIOISOTOPES
SYMPTOMS
SYNTHESIS
THERAPY
TRACER TECHNIQUES
VASCULAR DISEASES