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Threshold reduction for /sup 10/B concentration measurements using CR-39

Conference · · Trans. Am. Nucl. Soc.; (United States)
OSTI ID:7063727
; ; ; ; ;
As part of a study of the effectiveness of /sup 10/B as a capture agent for neutron capture therapy, the /sup 10/B concentrations of samples of blood of rats are being measured following administration of pharmaceuticals. The measurements are made with the polycarbonate Solid State Nuclear Track Detector (SSNTD) CR-39, using an autoradiographic procedure and an image analysis system for automatic track counting. Boron-10 concentrations in tissue have been measured by others using autoradiography and lexan and cellulose nitrate SSNTDs. The authors procedure for measuring /sup 10/B concentrations in blood using CR-39 has been reported in detail previously. This paper discusses the reduction in the minimum detectable /sup 10/B concentration, which can be achieved by carefully choosing the lower level discriminator (LLD) for track area (the track area below which tracks are not counted), so that protons from the /sup 14/N(n,p)/sup 14/C reaction are discriminated against relative to the tracks of the /sup 10/B(n,..cap alpha..)/sup 7/Li charged reaction products.
Research Organization:
Ohio State Univ., Columbus
OSTI ID:
7063727
Report Number(s):
CONF-861102-
Conference Information:
Journal Name: Trans. Am. Nucl. Soc.; (United States) Journal Volume: 53
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
ANTIGENS
BLOOD SUBSTITUTES
BORON 10
BORON ISOTOPES
CARBOHYDRATES
DEXTRAN
DISEASES
DRUGS
HEMATOLOGIC AGENTS
ISOTOPES
LIGHT NUCLEI
MEDICINE
MELANOMAS
MONOCLONAL ANTIBODIES
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
POLYSACCHARIDES
RADIOASSAY
RADIOLOGY
RADIOTHERAPY
SACCHARIDES
STABLE ISOTOPES
THERAPY
UPTAKE