Determining deposition sites of inhaled lung particles and their effect on clearance

Journal Article · Sun Apr 01 04:00:00 EDT 1990 · Journal of Applied Physiology (1985); (USA)

OSTI ID:7063413

Langenback, E G; Bergofsky, E H; Halpern, J G; Foster, W M ^[1]

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1. State Univ. of New York, Stony Brook (USA)

An essential component of lung defense is clearance of particulates and infectious vectors from the mucus membrane of the tracheobronchial tree and the alveolar regions of the lung. To partition clearance between these areas we determined the bronchial branching pattern, the anatomical sites of particle deposition, and subsequent clearance in the same animal. Using a 2.85-microns particle tagged with 57Co for inhalation and deposition in the sheep lung, we followed clearance via a series of computer-stored gamma-scintillation lung images. The same sheep was reinhaled, and the particle distributions for both inhalations were compared. After the animals were killed, the bronchial branching pattern and length of the bronchial tree were documented. The number of particles depositing in all bronchi down to 1 mm diam was determined by scintillation counting, and the number in respiratory bronchioles and alveoli was microscopically counted. We conclude that particles deposited in bronchi greater than or equal to 1 mm diam clear in 2-4 h postdeposition. Bronchi distal to 1-mm-diam bronchi and alveoli clear evenly over 72 h, and the number of particles equal to the tracheobronchial deposition cleared after 45 h.

• OSTI ID: 7063413
• Journal Information: Journal of Applied Physiology (1985); (USA), Journal Name: Journal of Applied Physiology (1985); (USA) Vol. 68:4; ISSN 8750-7587; ISSN JAPHE
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
BRONCHI
CLEARANCE
COBALT 57
COBALT ISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOMESTIC ANIMALS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
MATERIALS
MICROSPHERES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
PARTICLE SIZE
PARTICLES
PARTICULATES
PETROCHEMICALS
PETROLEUM PRODUCTS
PLASTICS
POLYMERS
POLYOLEFINS
POLYSTYRENE
POLYVINYLS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
RUMINANTS
SCINTISCANNING
SHEEP
SIZE
SYNTHETIC MATERIALS
TRACHEA
VERTEBRATES