Assignment of the human gene for the [alpha][sub 1] subunit of the skeletal muscle DHP-sensitive Ca[sup 2+] channel (CACNL1A3) to chromosome 1q31-q32

Journal Article · Thu Dec 31 23:00:00 EST 1992 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1017· OSTI ID:7063337

Gregg, R G; Couch, F; Hogan, K; Powers, P A ^[1]

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1. Univ. of Wisconsin, Madison (United States)

A human clone corresponding to the gene encoding the [alpha][sub 1] subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (CACNL1A3) has been isolated and partially sequenced. Oligonucleotides based on this sequence were used in a polymerase chain reaction to amplify specifically the human gene in human-rodent somatic cell hybrids, allowing the assignment of CACNL1A3 to chromosome 1. A polymorphic dinucleotide repeat also was identified in the human clone and using PCR was typed on a subset of the CEPH families. Multipoint linkage analysis places the CACNL1A3 gene between D1S52 and D1S70, on chromosome 1q31-q32. 40 refs., 3 figs., 3 tabs.

• OSTI ID: 7063337
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 15:1; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH METALS
ANIMAL CELLS
AZINES
CALCIUM
CELL CONSTITUENTS
CELL MEMBRANES
CHROMOSOMES
DEPOLARIZATION
DNA SEQUENCING
ELEMENTS
GENES
GENETIC MAPPING
HETEROCYCLIC COMPOUNDS
HUMAN CHROMOSOMES
MAPPING
MEMBRANES
METALS
MUSCLES
NUCLEIC ACIDS
OLIGONUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
SIGNALS
STRUCTURAL CHEMICAL ANALYSIS