Assignment of the human gene for the [beta] subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping

Journal Article · Thu Dec 31 23:00:00 EST 1992 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1029· OSTI ID:6697307

Gregg, R G; Powers, P A; Hogan, K ^[1]

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1. Univ. of Wisconsin, Madison (United States)

A human clone containing a portion of the gene encoding several isoforms of the 31 subunit of voltage-dependent calcium channels was isolated and partially sequenced. The gene was mapped to chromosome 17 using the polymerase chain reaction with oligonucleotides that allowed the specific amplification of the human sequence in the human-rodent hybrids. A polymorphic dinucleotide repeat was identified within the gene and typed on a subset of the CEPH families. Using multipoint linkage analysis the most likely location of the [beta][sub 1] subunit gene is between D17S36 and NGFR on chromosome 17q11.2-q22. 9 refs., 1 fig., 1 tab.

• OSTI ID: 6697307
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 15:1; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH METALS
AMPLIFICATION
ANIMAL CELLS
CALCIUM
CELL CONSTITUENTS
CELL MEMBRANES
CHROMOSOMES
ELEMENTS
GENETIC MAPPING
HUMAN CHROMOSOME 17
HUMAN CHROMOSOMES
MAPPING
MEMBRANE PROTEINS
MEMBRANES
METALS
NUCLEIC ACIDS
OLIGONUCLEOTIDES
ORGANIC COMPOUNDS
PROTEINS
SOMATIC CELLS