Serum squamous cell carcinoma antigen in the monitoring of radiotherapy treatment response in carcinoma of the cervix

Journal Article · Tue May 01 04:00:00 EDT 1990 · Gynecologic Oncology; (USA)

DOI:https://doi.org/10.1016/0090-8258(90)90344-K· OSTI ID:7062788

Ngan, H Y; Chan, S Y; Wong, L C; Choy, D T; Ma, H K ^[1]

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1. Univ. of Hong Kong (Hong Kong)

In this study, squamous cell carcinoma antigen (SCC) was detected in 96 of 157 patients with squamous cell carcinoma of the cervix and the percentage of patients with raised SCC levels increased with the stage of disease (P less than 0.01). The use of serial SCC assays and cervical biopsy histology during the course of radiotherapy to predict tumor response to irradiation was assessed. In patients who were given external irradiation before intracavitary radium, a high SCC level or the presence of viable tumor cells in the biopsy was found to be of no predictive value. However, at completion of radiotherapy, i.e., after intracavitary radium application, patients with persistently high SCC levels had a significantly higher incidence of residual tumor than patients whose SCC levels returned to normal (P less than 0.01). In 60% of patients with a persistently high SCC level, viable tumor was found in the cervical biopsy at the end of radiotherapy. On the other hand, only 5.4% of patients whose SCC level returned to normal had residual tumor.

• OSTI ID: 7062788
• Journal Information: Gynecologic Oncology; (USA), Journal Name: Gynecologic Oncology; (USA) Vol. 37:2; ISSN GYNOA; ISSN 0090-8258
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALINE EARTH ISOTOPES
ANIMALS
ANTIGENS
BIOPSY
BODY
CARCINOMAS
DIAGNOSTIC TECHNIQUES
DISEASES
FEMALE GENITALS
FEMALES
ISOTOPES
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PRIMATES
RADIOLOGY
RADIOTHERAPY
RADIUM ISOTOPES
THERAPY
UTERUS
VERTEBRATES