CERVICAL CARCINOMA IN SITU AND ANAL SQUAMOUS-CELL CARCINOMA FOLLOWING RADIATION THERAPY FOR SQUAMOUS-CELL CARCINOMA OF CERVIX

Journal Article · Tue Oct 01 04:00:00 EDT 1963 · Obstetrics and Gynecology (U.S.)

OSTI ID:4113033

Cavins, A W

A case report is cited illustrating the development of carcinoma of the uterine cervix 18 yr after successful radiation treatment of a previous cervical carcinoma. The 23-yr-old patient had a rapidly growing squamouscell carcinoma of highest grade of malignancy in 1943. She was given deep x-ray therapy using 4 ports, 10 x 15 cm, 200 kv, and 20 ma on 20 different days for a total of 6720 r (168 r to each of 2 ports per treatment). Radium in a total dose of 5400 mg-hr was also given. Subsequent repeated examinations showed total disappearance of the tumor, but in 1961 a cervical biopsy showed carcinoma in situ with no evidence of invasive or recurrent carcinoma. Recovery from this presumably primary tumor was complete but another apparently primary tumor developed in the rectum, diagnosed as a moderately differentiated squamous-cell carcinoma. Eight previously reported cases of such an in situ carcinoma developing after radiotherapy are reviewed. Various sequelae of radiation injury of the gastrointestinal and genitourinary tracts are described as a result of pathologic study of the case and their significance discussed. (BBB)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-18-009951
• OSTI ID: 4113033
• Journal Information: Obstetrics and Gynecology (U.S.), Journal Name: Obstetrics and Gynecology (U.S.) Vol. Vol: 22; ISSN OBGNA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
CANCER
CARCINOMAS
GONADS
INTESTINE
MAN
MICROSCOPY
RADIATION DOSES
RADIATION INJURIES
RADIOTHERAPY
RADIUM
RECOVERY
RECTUM
TISSUES
UTERUS
X RADIATION