Randomized trial comparing single dose versus fractionated irradiation for prevention of heterotopic bone: A preliminary report

Journal Article · Tue May 01 04:00:00 EDT 1990 · International Journal of Radiation Oncology, Biology and Physics; (USA)

DOI:https://doi.org/10.1016/0360-3016(90)90450-X· OSTI ID:7062774

Konski, A; Pellegrini, V; Poulter, C; DeVanny, J; Rosier, R; Evarts, C M; Henzler, M; Rubin, P ^[1]

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1. Strong Memorial Hospital, Rochester, NY (USA)

Radiation therapy has been shown to prevent heterotopic bone formation in high risk patients undergoing total hip replacement. A number of doses have been used without a randomized trial comparing one dose regimen against another. A prospective randomized trial was undertaken comparing 10 Gy in 5 fractions versus 8 Gy in 1 fraction. Forty-seven patients have been randomized at the time of this evaluation with 37 patients eligible for analysis. The pre-operative, immediate post-operative and 2 month post-operative radiographs were graded. At the time of this analysis, 17 patients were randomized to the 8 Gy arm with 20 patients in the 10 Gy arm. Patients were treated with limited fields so as to only cover the area at risk for development of heterotopic bone to prevent adverse effects on biologic fixation of uncemented implants. When comparing the pre-operative, operative, and 2 month post-operative radiographs, only four patients (1 patient in the 8 Gy arm and 3 patients in the 10 Gy arm), had an increase in the score. No patient had an increase in score to a clinically significant level, usually grade 3 or 4. These preliminary results appear to show that 8 Gy in a single fraction can be as effective as 10 Gy in 5 fractions in preventing heterotopic bone in susceptible individuals. Further follow-up of the remaining patients may confirm this.

• OSTI ID: 7062774
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (USA), Journal Name: International Journal of Radiation Oncology, Biology and Physics; (USA) Vol. 18:5; ISSN IOBPD; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BODY
BODY AREAS
BONE JOINTS
DISEASES
FRACTIONATED IRRADIATION
IRRADIATION
MAMMALS
MAN
MEDICAL SUPPLIES
MEDICINE
NUCLEAR MEDICINE
ORGANS
PATIENTS
PELVIS
PRIMATES
PROSTHESES
RADIOLOGY
RADIOTHERAPY
SKELETAL DISEASES
SKELETON
THERAPY
VERTEBRATES