The gene for the retinal pigment epithelium-specific protein RPE65 is localized to human 1p31 and mouse 3

Journal Article · Fri Apr 01 04:00:00 EST 1994 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1994.1212· OSTI ID:7062522

Hamel, C P; Redmond, T M ^[1]; Jenkins, N A; Gilbert, D J; Copeland, N G ^[2]

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1. National Institutes of Health, Bethesda, MD (United States)
2. Mammalian Genetics Lab., Frederick, MD (United States)

The human and murine chromosomal localization for the gene for the retinal pigment epithelium-specific protein RPE65 was determined. Using interspecific backcross analysis, the authors mapped Rpe65 to the distal end of mouse chromosome 3. In the human, using a human-hamster hybrid panel, RPE65 was mapped to chromosome 1. By the use of fluorescence in situ hybridization, this localization was refined to 1p31. The mouse and human loci for this potential candidate gene for hereditary retinal disease do not match those of any known disease in mouse or man. 10 refs., 3 figs., 1 tab.

• OSTI ID: 7062522
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 20:3; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
BODY
BODY AREAS
CHROMOSOMES
DISEASES
DNA HYBRIDIZATION
EPITHELIUM
EYES
FACE
GENETIC MAPPING
HEAD
HEREDITARY DISEASES
HUMAN CHROMOSOME 1
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
ORGANS
RETINA
SENSE ORGANS
TISSUES