Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens
- Univ. of Pennsylvania, Philadelphia, PA (United States); and others
We have determined the chromosomal localization of the murine gene encoding a 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b). Using two independent approaches, fluorescence in situ hybridization and interspecific backcross analysis, we show that Inpp5b maps to distal mouse chromosome 4. This map position is within the conserved linkage group corresponding to the short arm of human chromosome 1, where the human homologue, INPP5B, has been shown to map previously. The position of Inpp5b on mouse chromosome 4 is the vicinity of the mouse developmental mutation dysgenetic lens (dyl). However, using a genetic approach, we show that Inpp5b maps distal to dyl on mouse chromosome 4. 32 refs., 3 figs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 390932
- Journal Information:
- Genomics, Vol. 28, Issue 2; Other Information: PBD: 20 Jul 1995
- Country of Publication:
- United States
- Language:
- English
Similar Records
Identification and chromosomal mapping of the mouse inositol polyphosphate 1-phosphatase gene
Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization
The murine homeobox genes Nkx2.3 and Nkx2.6 are located on chromosomes 19 and 14, respectively
Journal Article
·
Mon Nov 20 00:00:00 EST 1995
· Genomics
·
OSTI ID:390932
Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization
Journal Article
·
Mon Jan 01 00:00:00 EST 1996
· Genomics
·
OSTI ID:390932
+1 more
The murine homeobox genes Nkx2.3 and Nkx2.6 are located on chromosomes 19 and 14, respectively
Journal Article
·
Mon Aug 01 00:00:00 EDT 1994
· Genomics
·
OSTI ID:390932