A 1-year time course study of the relaxation times and histology for irradiated rat lungs

Journal Article · Tue May 01 04:00:00 EDT 1990 · Magnetic Resonance in Medicine; (USA)

DOI:https://doi.org/10.1002/mrm.1910140220· OSTI ID:7062123

Shioya, S; Haida, M; Fukuzaki, M; Ono, Y; Tsuda, M; Ohta, Y; Yamabayashi, H ^[1]

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1. Tokai Univ. School of Medicine, Kanagawa (Japan)

To investigate the NMR relaxation times for irradiated rat lung tissue, we measured T1 and T2 at 11 different times during the injury's 1-year time course. A biexponential analysis of T2 was used to determine T2 fast (T2f) and T2 slow (T2s). In addition, we measured water content and correlated changes in the relaxation times with pathological changes. The correlation indicates the following: (1) Shortly after irradiation, the biexponential T2 decay for 1/3 of the samples became monoexponential and there were no noticeable pathological changes observed using light microscopy. (2) During radiation pneumonitis, T2f and T2s were prolonged. This accompanied acute edematous changes and inflammatory cell infiltration. (3) Finally, during radiation fibrosis T1 shortened and collagen increased. We observed no significant correlation between relaxation time changes and water content changes throughout the 1-year time course.

• OSTI ID: 7062123
• Journal Information: Magnetic Resonance in Medicine; (USA), Journal Name: Magnetic Resonance in Medicine; (USA) Vol. 14:2; ISSN 0740-3194; ISSN MRMEE
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIAGNOSTIC TECHNIQUES
FIBROSIS
INJURIES
LUNGS
MAMMALS
NMR IMAGING
ORGANS
PATHOLOGICAL CHANGES
PNEUMONITIS
RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
RATS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES