Toxicity of metallic ions and oxides to rabbit alveolar macrophages

Journal Article · Sat Apr 01 00:00:00 EST 1989 · Environmental Research; (USA)

DOI:https://doi.org/10.1016/S0013-9351(89)80039-8· OSTI ID:7059152

Labedzka, M; Gulyas, H; Schmidt, N; Gercken, G ^[1]

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1. Univ. of Hamburg (Germany, F.R.)

The effects of soluble compounds and oxides of As, Cd, Cu, Hg, Ni, Pb, Sb, Sn, V, and Zn on oxidative metabolism and membrane integrity of rabbit alveolar macrophages were studied by 24-hr in vitro exposure. Oxidative metabolism induced by phagocytosis of opsonized zymosan was measured by H{sub 2}O{sub 2} and O{sub 2}{sup {minus}} release and by chemiluminescence in the presence of luminol. Membrane integrity was estimated by extracellular LDH activity. Metallic ions and oxides inhibited the release of active oxygen species. Cd(II), As(III), and V(V) were the most toxic elements as measured by all investigated parameters. Cu(II) decreased O{sub 2}{sup {minus}} release and chemiluminescence effectively but H{sub 2}O{sub 2} release and membrane integrity less. Chemiluminescence was decreased strongly by Hg(II) while O{sub 2}{sup {minus}} and H{sub 2}O{sub 2} release were depressed moderately. Zn(II) and Sb(III) compounds caused medium toxicity and the tested Sn, Ni, and Pb compounds showed only faint toxic effects.

• OSTI ID: 7059152
• Journal Information: Environmental Research; (USA), Vol. 48:2; ISSN 0013-9351
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIMONY
TOXICITY
ARSENIC COMPOUNDS
CADMIUM COMPOUNDS
COPPER COMPOUNDS
LEAD COMPOUNDS
MACROPHAGES
INJURIES
MERCURY COMPOUNDS
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ELEMENTS
HYDROGEN COMPOUNDS
LUMINESCENCE
MEMBRANES
METALS
NONMETALS
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