Tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate elevates serum progesterone levels
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
The phorbol ester 12-0-tetradecanoyl-13-acetate (TPA), the most potent promoter of two-stage carcinogenesis in mouse skin, simulates some of the early effects of several carcinogens in immature chicks. Actinomycin D, ethionine, thioacetamide (non-mutagenic in the Ames Salmonella test) and kepone are known to increase serum progesterone concentrations and induce synthesis of ovalbumin in chicks. Intraperitoneal administration of TPA to chicks caused a 5- to 7-fold elevation of serum progesterone levels and induced ovalbumin synthesis. Phorbol ester, 4..cap alpha..-phorbol-12, 13-didecanoate, which is inactive as a mouse skin tumor promoter, did not increase serum progesterone levels nor did it induce ovalbumin synthesis.
- Research Organization:
- AMC Cancer Research Center, Lakewood, CO
- OSTI ID:
- 7055868
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 87:4; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINOMYCIN
ALBUMINS
AMINO ACIDS
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BIRDS
BLOOD SERUM
BODY
CARBOXYLIC ACIDS
CARCINOGENESIS
CARCINOGENS
CHICKENS
CROTON OIL
DATA
DISEASES
DRUGS
ESTERS
ETHIONINE
EXPERIMENTAL DATA
FOWL
HORMONES
INFORMATION
INSECTICIDES
KEPONE
KETONES
LIPIDS
LIPOTROPIC FACTORS
MAMMALS
MICE
NEOPLASMS
NUMERICAL DATA
OILS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
PESTICIDES
PREGNANES
PROGESTERONE
PROMOTERS
PROTEINS
RODENTS
SESAME OIL
SKIN
STEROID HORMONES
STEROIDS
SYNTHESIS
TRIGLYCERIDES
TUMOR PROMOTERS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINOMYCIN
ALBUMINS
AMINO ACIDS
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BIRDS
BLOOD SERUM
BODY
CARBOXYLIC ACIDS
CARCINOGENESIS
CARCINOGENS
CHICKENS
CROTON OIL
DATA
DISEASES
DRUGS
ESTERS
ETHIONINE
EXPERIMENTAL DATA
FOWL
HORMONES
INFORMATION
INSECTICIDES
KEPONE
KETONES
LIPIDS
LIPOTROPIC FACTORS
MAMMALS
MICE
NEOPLASMS
NUMERICAL DATA
OILS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
PESTICIDES
PREGNANES
PROGESTERONE
PROMOTERS
PROTEINS
RODENTS
SESAME OIL
SKIN
STEROID HORMONES
STEROIDS
SYNTHESIS
TRIGLYCERIDES
TUMOR PROMOTERS
VERTEBRATES