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Disappearance rate of endogenously radioiodinated thyroglobulin and thyroxine after radioiodine treatment

Journal Article · · Cancer (Philadelphia); (United States)
; ; ;
Endogenously radioiodinated thyroglobulin (tg) and thyroxine (T4), in the circulation following, therapeutic doses of radioiodine were studied in five patients with differentiated thyroid carcinoma. Radioactive serum was fractionated on a Sephadex G-200 and the various radioactive peaks thus obtained were analyzed for their biochemical and immunologic characteristics using precipitation with trichloroacetic acid (TCA) and antithyroglobulin antibody extraction with acidified n-butanol and electrophoresis on agar gel. The disappearance rates of endogenously labelled tg and T4 were 3.12 +/- 0.396 days and 10.14 +/- 1.81 days, respectively.
Research Organization:
Radiation Medicine Centre, Bhabha Atomic Research Centre, Bombay, India
OSTI ID:
7055168
Journal Information:
Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 49:11; ISSN CANCA
Country of Publication:
United States
Language:
English

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Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETIC ACID
AMINO ACIDS
BIOCHEMISTRY
BIOLOGICAL HALF-LIFE
BODY
CARBOXYLIC ACIDS
CARCINOMAS
CHEMICAL ANALYSIS
CHEMISTRY
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROPHORESIS
ENDOCRINE GLANDS
GLANDS
GLOBULINS
HORMONES
IMMUNE REACTIONS
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MEDICINE
MONOCARBOXYLIC ACIDS
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
PROTEINS
QUANTITATIVE CHEMICAL ANALYSIS
RADIOLOGY
RADIONUCLIDE KINETICS
RADIOTHERAPY
THERAPY
THYROGLOBULIN
THYROID
THYROID HORMONES
THYROXINE