Tc-99m human serum albumin: a suitable agent for plasma volume measurements in man. [Comparision with /sup 131/I-HSA]

Journal Article · Sat Jul 01 04:00:00 EDT 1978 · J. Nucl. Med.; (United States)

OSTI ID:7053568

Yang, S S.L.; Nickoloff, E L; McIntyre, P A; Maddrey, W C; Mikesell, H H; Scheffel, U; Kasecamp, W; MacAllister, N P

In 16 patients we have carried out simultaneous plasma-volume measurements with human serum albumins tagged with Tc-99m (Tc-99m HSA) and I-131 (I-131 HSA). The correlation coefficient was 0.987. Tc-99m HSA, prepared from kits that predictably yield high labeling efficiency (and thereby negligible amounts of TcO/sub 4//sup -/), is clearly a superior agent for repeat plasma volume determinations, because of its shorter half-life and the reduced radiation dose to the subject.

• Research Organization: Johns Hopkins Medical Institutions, Baltimore
• OSTI ID: 7053568
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 19:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

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560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BLOOD SERUM
BODY FLUIDS
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DOSES
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MAN
MEASURING METHODS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RADIATION DOSES
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOPHARMACEUTICALS
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
VOLUME
YEARS LIVING RADIOISOTOPES