Radiation effects on life span in Caenorhabditis elegans
Wild-type and radiation-sensitive (Rad) mutants of Caenorhabditis elegans were irradiated using a /sup 137/Cs source (2.7 krads/min.) at several developmental stages and subsequently monitored for life span. Acute doses of radiation ranged from 1 krad to 300 krads. All stages required doses above 100 krads to reduce mean life span. Dauers and third stage larvae were more sensitive, and 8-day-old adults were the most resistant. Occasional statistically significant but nonrepeatable increases in survival were observed after intermediate levels of irradiation (10-30 krads). Unirradiated rad-4 and rad-7 had life spans similar to wild-type; all others had a significant reduction in survival. The mutants were about as sensitive as wild-type to the effects of ionizing radiation including occasional moderate life span extensions at intermediate doses. We conclude that the moderate life span extensions sometimes observed after irradiation are likely to be mediated by a means other than the induction of DNA repair enzymes.
- Research Organization:
- Univ. of California, Irvine (USA)
- OSTI ID:
- 7053063
- Journal Information:
- J. Gerontol.; (United States), Journal Name: J. Gerontol.; (United States) Vol. 43:5; ISSN JOGEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
AGE DEPENDENCE
ALKALI METAL ISOTOPES
ASCHELMINTHES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CESIUM 137
CESIUM ISOTOPES
DNA REPAIR
DOSES
HELMINTHS
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LARVAE
LIFE SPAN
NEMATODES
NUCLEI
ODD-EVEN NUCLEI
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RECOVERY
REPAIR
YEARS LIVING RADIOISOTOPES