The development of in vitro mutagenicity testing systems using T-lymphocytes
This work has focused on the development of in vitro T-cell mutation assays. Conditions have been defined to measure the in vitro induction of mutations at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus in human T-lymphocytes. This assay is a parallel to our in vivo hprt assay, in that the same cells are utilized. However, the in vitro assay allows for carefully controlled dose response studies. 21 refs., 16 figs., 13 tabs.
- Research Organization:
- Vermont Univ., Burlington, VT (United States)
- Sponsoring Organization:
- DOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-87ER60502
- OSTI ID:
- 7049865
- Report Number(s):
- DOE/ER/60502-6; ON: DE92015918
- Country of Publication:
- United States
- Language:
- English
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The development of in vitro mutagenicity testing systems using T-lymphocytes. Research progress report, November 1, 1989--April 30, 1992
Molecular and clonal analysis of in vivo hprt (hypoxanthine-guanine phosphoribosyl-transferase) mutations in human cells
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OSTI ID:10154144
Molecular and clonal analysis of in vivo hprt (hypoxanthine-guanine phosphoribosyl-transferase) mutations in human cells
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Tue Aug 08 00:00:00 EDT 1989
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OSTI ID:6708412
The development of in vitro mutagenicity testing systems using T-lymphocytes: Research progress report: June 1, 1988--May 31, 1989
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Mon May 01 00:00:00 EDT 1989
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OSTI ID:6098183
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