Synthesis of tracers using automated radiochemistry and robotics
Synthesis of high specific activity radiotracers labeled with short-lived positron-emitting radionuclides for positron emission tomography (PET) often requires handling large initial quantities of radioactivity. High specific activities are required when preparing tracers for use in PET studies of neuroreceptors. A fully automated approach for tracer synthesis is highly desirable. This proposal involves the development of a system for the Synthesis of Tracers using Automated Radiochemistry and Robotics (STARR) for this purpose. While the long range objective of the proposed research is the development of a totally automated radiochemistry system for the production of major high specific activity {sup 11}C-radiotracers for use in PET, the specific short range objectives are the automation of {sup 11}C-methyl iodide ({sup 11}CH{sub 3}I) production via an integrated approach using both radiochemistry modular labstations and robotics, and the extension of this automated capability to the production of several radiotracers for PET (initially, {sup 11}C-methionine, 3-N-({sup 11}C-methyl)spiperone, and ({sup 11}C)-carfentanil).
- Research Organization:
- Johns Hopkins Univ., Baltimore, MD (United States). School of Medicine
- Sponsoring Organization:
- DOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-90ER61006
- OSTI ID:
- 7030007
- Report Number(s):
- DOE/ER/61006-T1; ON: DE92019525
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
AUTOMATION
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBON 11
CARBON ISOTOPES
CHEMICAL PREPARATION
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOCUMENT TYPES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HALOGENATED ALIPHATIC HYDROCARBONS
IODINATED ALIPHATIC HYDROCARBONS
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
METHYL IODIDE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
ROBOTS
SYNTHESIS
TOMOGRAPHY
TRACER TECHNIQUES