In situ method for estimating cell survival in a solid tumor
The response of the murine Meth-A fibrosarcoma to single and fractionated doses of x-irradiation, actinomycin D chemotherapy, and/or concomitant local tumor hyperthermia was assayed with the use of an in situ method for estimating cell kill within a solid tumor. The cell survival assay was based on a standard curve plotting number of inoculated viable cells with and without radiation-inactivated homologous tumor cells versus the time required for i.m. tumors to grow to 1.0 cu cm. The time for post-treatment tumors to grow to 1.0 cu cm was cross-referenced to the standard curve, and the number of surviving cells contributing to tumor regrowth was estimated. The resulting surviving fraction curves closely resemble those obtained with in vitro systems.
- Research Organization:
- Memorial Sloan-Kettering Cancer Center, New York, NY
- OSTI ID:
- 7028836
- Journal Information:
- Cancer Res.; (United States), Vol. 38:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ACTINOMYCIN
EVALUATION
ACUTE IRRADIATION
DOSE-RESPONSE RELATIONSHIPS
CELL KILLING
RADIOINDUCTION
HYPERTHERMIA
TUMOR CELLS
BIOLOGICAL RADIATION EFFECTS
FIBROSARCOMAS
FRACTIONATED IRRADIATION
IN VIVO
X RADIATION
ACUTE EXPOSURE
ANIMAL CELLS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BODY TEMPERATURE
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
NEOPLASMS
RADIATION EFFECTS
RADIATIONS
SARCOMAS
560152* - Radiation Effects on Animals- Animals