Effects of in utero exposure to cyclophosphamide in mice. II. Assessment of immunocompetence of offspring from 5 to 10 weeks of age

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Immunopharmacology and Immunotoxicology; (USA)

DOI:https://doi.org/10.3109/08923978909005365· OSTI ID:7027291

Liakopoulou, A; Buttar, H S; Nera, E A; Fernando, L ^[1]

---

1. Health and Welfare Canada, Ottawa, Ontario (Canada)

Offspring of mice treated with cyclophosphamide (Cy; 1, 2.5 or 5 mg/kg) during pregnancy (6-18 days of gestation) and tested for immunocompetence from 5 to 10 weeks of age were found to have defective reticuloendothelial clearance. The main effects were: (a) increased elimination half time (T 1/2) of {sup 51}Cr-labeled SRBC from circulation, (b) decreased liver uptake of {sup 51}Cr and (c) impaired ability of the spleen, mostly affecting the female pups, to compensate for decreased liver uptake. The highest dose group suffered the most pronounced effects. This group was also found to have increased IgG immunoglobulin levels at 7 weeks of age. IgG antibody production in response to specific antigenic stimulation and delayed hypersensitivity reactions to oxazolone did not appear to be affected by Cy treatment.

• OSTI ID: 7027291
• Journal Information: Immunopharmacology and Immunotoxicology; (USA), Vol. 11:2-3; ISSN 0892-3973
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
RETICULOENDOTHELIAL SYSTEM
SENSITIVITY
BIOLOGICAL HALF-LIFE
CHROMIUM 51
IMMUNOGLOBULINS
METABOLISM
MICE
PREGNANCY
PRENATAL EXPOSURE
TRACER TECHNIQUES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CHROMIUM ISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLOBULINS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
RODENTS
TISSUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques