Growth and development of mice offspring after irradiation in utero with 2,450-MHz microwaves
Mice offspring irradiated in utero with 2,450-MHz radio-frequency (RF) radiation at 0 or 28 mW/cm2 (whole-body averaged specific absorption rate . 0 or 16.5 W/kg) for 100 minutes daily on days 6 through 17 of gestation were evaluated for maturation and development on days 1, 5, 10, 12, 15, and 17 of age. The tests used to determine differences in developmental age in the two treatment groups were body weight, urine concentrating ability, brain weight, tolerance to ouabain, and bone lengths. Fifteen sham-irradiated and 26 RF-irradiated litters, normalized to eight pups/litter, were used in this study. Mean body weight of the microwave-irradiated offspring were significantly (p . .0003) decreased only on day 1 of age. Brain weight on days 10, 12, and 17 were significantly lower in microwave-irradiated pups (p . .01). There were no significant differences in the two groups in urine concentrating ability on day 5, ouabain tolerance on day 15, or bone length on days 5, 10, 12, and 17. It is concluded that there is a persistent delay in postnatal development of the brain after RF irradiation with 16.5 W/kg during gestation.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC
- OSTI ID:
- 5660969
- Journal Information:
- Teratology; (United States), Journal Name: Teratology; (United States) Vol. 30:3; ISSN TJADA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL GROWTH
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
BRAIN
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DELAYED RADIATION EFFECTS
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FEMALE GENITALS
GLYCOSIDES
GROWTH
IRRADIATION
MAMMALS
MATERIALS
MICE
MICROWAVE RADIATION
NEONATES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
OUABAIN
PRENATAL EXPOSURE
PRENATAL IRRADIATION
PROGENY
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RODENTS
SKELETON
STROPHANTHINS
URINE
UTERUS
VERTEBRATES
WASTES
WEIGHT
WHOLE-BODY IRRADIATION