Human biodistribution of sup 111 In-labeled B72. 3 monoclonal antibody

Journal Article · Wed Jan 31 23:00:00 EST 1990 · Cancer Research; (USA)

OSTI ID:7026480

Harwood, S J; Carroll, R G; Webster, W B; Zangara, L M; Laven, D L; Morrissey, M A; Sinni, B J ^[1]

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1. Bay Pines Veterans Administration Medical Center, FL (USA)

The murine IgG1 monoclonal antibody B72.3 reacts with human colorectal, breast, lung, pancreatic, gastric, and ovarian tumors. Human biodistribution studies using intact {sup 131}I-B72.3 have been reported by Carrasquillo et al.. We have performed similar studies on five patients using i.v. infusion of 20 mg of intact {sup 111}In-B72.3 (Cytogen Corp.). Serum clearance is similar with a t1/2 of 64.2 h (range, 44-80) for {sup 111}In-B72.3 and 65 h (range, 32-106) for {sup 131}I-B72.3. However, organ biodistribution is markedly different. For {sup 131}I-B72.3, hepatic and splenic clearance mirrors blood pool clearance. For {sup 111}In-B72.3, there is rapid uptake in tumor, liver, spleen, kidney, lumbar spine, and testes by 2-6 h with no significant clearance over the next 9 days. For {sup 111}In-B72.3, quantitative analysis of liver (from biopsy specimens), spleen, kidney, and lumbar spine (from scintiphoto regions of interest after background subtraction and attenuation correction) shows the following peak organ biodistributions in percentage infused dose: liver, 32%; spleen, 3.9%; kidneys, 3.5%; and lumbar vertebral bodies (marrow sample), 2.7%. For both {sup 111}In-B72.3 and {sup 131}I-B72.3, the principal route of excretion from the body is urinary with excretion rate of {sup 131}I faster than {sup 111}In. The marked differences between {sup 111}In-B72.3 and {sup 131}I-B72.3 biodistribution and clearance strongly influence the dosimetry, immunodetection, and immunotherapeutic potentials of B72.3 MoAb.

• OSTI ID: 7026480
• Journal Information: Cancer Research; (USA), Journal Name: Cancer Research; (USA) Vol. 50; ISSN CNREA; ISSN 0008-5472
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD-PLASMA CLEARANCE
CLEARANCE
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
IMMUNOLOGY
IMMUNOTHERAPY
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MAN
MEDICINE
METABOLISM
MICE
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
PRIMATES
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RADIOIMMUNOSCINTIGRAPHY
RADIOIMMUNOTHERAPY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
SCINTISCANNING
THERAPEUTIC USES
THERAPY
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
USES
VERTEBRATES