Role of antibody in recovery from experimental rabies. I. Effect of depletion of B and T cells
The avirulent high egg passage (HEP) strain of rabies virus produces an inapparent infection limited to the central nervous system (CNS) in intracerebrally inoculated adult mice. Heavy chain isotype (anti-..mu.. antiserum) immunosuppression potentiates the infection, with a mortality of about 60% and with elevated virus titers in the brain. Anti-..mu..-treated mice fail to raise antibody responses to rabies virus although their T cell function is normal when measured by the concanavalin A response of splenic lymphocytes. This indicates that the B cell response plays an important role in clearance of rabies virus from the neuroparenchyma. Treatment with cyclophosphamide or by adult thymectomy, x-irradiation, and bone marrow reconstitution potentiates HEP infection to a greater extent than does isotype supression. Since these suppressive techniques impair both T and B lymphocyte responses, the data suggest that cellular immune mechanisms may also contribute to host defenses against this central nervous system (CNS) virus infection.
- Research Organization:
- Johns Hopkins Univ., Baltimore
- OSTI ID:
- 7025396
- Journal Information:
- J. Immunol.; (United States), Vol. 121:1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ANTIBODY FORMATION
INHIBITION
IMMUNE REACTIONS
BIOLOGICAL RADIATION EFFECTS
IMMUNOSUPPRESSION
RADIOINDUCTION
LYMPHOCYTES
MICE
VIRUSES
INFECTIVITY
BONE MARROW CELLS
BRAIN
CESIUM 137
ENDOXAN
GAMMA RADIATION
IMMUNE SERUMS
LETHAL IRRADIATION
THYMECTOMY
TRANSPLANTS
WHOLE-BODY IRRADIATION
ALKALI METAL ISOTOPES
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LEUKOCYTES
MAMMALS
MEDICINE
MICROORGANISMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PARASITES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
SURGERY
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
551000 - Physiological Systems
550700 - Microbiology
550900 - Pathology