Role of antibody in recovery from experimental rabies. I. Effect of depletion of B and T cells

Journal Article · Sat Jul 01 04:00:00 EDT 1978 · J. Immunol.; (United States)

OSTI ID:7025396

Miller, A; Morse, III, H C; Winkelstein, J; Nathanson, N

The avirulent high egg passage (HEP) strain of rabies virus produces an inapparent infection limited to the central nervous system (CNS) in intracerebrally inoculated adult mice. Heavy chain isotype (anti-..mu.. antiserum) immunosuppression potentiates the infection, with a mortality of about 60% and with elevated virus titers in the brain. Anti-..mu..-treated mice fail to raise antibody responses to rabies virus although their T cell function is normal when measured by the concanavalin A response of splenic lymphocytes. This indicates that the B cell response plays an important role in clearance of rabies virus from the neuroparenchyma. Treatment with cyclophosphamide or by adult thymectomy, x-irradiation, and bone marrow reconstitution potentiates HEP infection to a greater extent than does isotype supression. Since these suppressive techniques impair both T and B lymphocyte responses, the data suggest that cellular immune mechanisms may also contribute to host defenses against this central nervous system (CNS) virus infection.

• Research Organization: Johns Hopkins Univ., Baltimore
• OSTI ID: 7025396
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 121:1; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

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560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
ANTIBODY FORMATION
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW CELLS
BRAIN
CENTRAL NERVOUS SYSTEM
CESIUM 137
CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DRUGS
ELECTROMAGNETIC RADIATION
ENDOXAN
EXTERNAL IRRADIATION
GAMMA RADIATION
IMMUNE REACTIONS
IMMUNE SERUMS
IMMUNOSUPPRESSION
INFECTIVITY
INHIBITION
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LETHAL IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MEDICINE
MICE
MICROORGANISMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PARASITES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SOMATIC CELLS
SURGERY
THYMECTOMY
TRANSPLANTS
VERTEBRATES
VIRUSES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES