Influence of immunosuppression on the growth of transplants of spontaneous mammary tumors in mice

Journal Article · Mon Jan 01 04:00:00 EST 1973 · Folia Biol. (Prague), v. 19, no. 6, pp. 414-419

OSTI ID:4367687

Gruntenko, E V

The following procedures suppressed the growth of syngeneic mammary tumours transplarted to mice infected with the mammary tumour virus: thymectomy at 6 days of age, injection of cyclophosphamide, 300R total-body irradiation, administration of antilymphocyte serum, thymectomy of adults with subsequent 750R irradiation, and administration of syngeneic bone marrow cells. Thymectomy of adult mice with subsequent 750R irradiation and administration of syngeneic bone marrow cells did not suppress the growth of a syngeneic hepatoma induced by a chemical carcinogen. Thymectomy at 6 days of age stimulated the growth of mammary tumours in virus-free mice (C57 BL x C3H)F/sub 1/. Evidence is presented supporting the suggestion that the growth of mammary tumour transplants is immunologically enhanced in virus-infected mice. (auth)

• Research Organization: Inst. of Cytology and Genetics, Novosibirsk, USSR
• NSA Number: NSA-29-018627
• OSTI ID: 4367687
• Journal Information: Folia Biol. (Prague), v. 19, no. 6, pp. 414-419, Journal Name: Folia Biol. (Prague), v. 19, no. 6, pp. 414-419; ISSN FOBLA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*ENDOXAN-- BIOLOGICAL EFFECTS
*MAMMARY GLANDS-- NEOPLASMS
*NEOPLASMS-- BIOLOGICAL RADIATION EFFECTS
*VIRUSES-- BIOLOGICAL EFFECTS
BONE MARROW CELLS
GROWTH
IMMUNOSUPPRESSION
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHOTON BEAMS
THYMECTOMY
TRANSPLANTS
X RADIATION