Total body irradiation and syngeneic marrow transplantation in an inbred rat model of acute myelogenous leukemia. [. gamma. rays; AML cell-marrow cell interactions in delayed relapse]

Journal Article · Sun Jan 01 00:00:00 EST 1978 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(78)90072-X· OSTI ID:7025358

Greenberger, J S ^[1]; Lockwood, C J; France, D S; McGrath, T; Moloney, W C

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1. Harvard Medicial School, Boston

While acute myelogenous leukemia (AML) occurs rarely in laboratory animals, over 20 model systems have been reported. One of these, AML of the inbred Wistar/Furth rat, has been shown to be pathophysiologically similar to human AML. Ten days after intravenous inoculation of 1.0 x 10/sup 6/ cells of a tissue culture grown clonal line, rats demonstrated peripheral blood leukemia, replacement of greater than 90% of the bone marrow with distinctive malignant myeloblasts and a syndrome of hypermuramidase (lysozyme) emia and muramidasuria. Total body irradiation (TBI) at 10 days after leukemia cell passage with a marrow lethal dose (950 rad, 140 rad/min, /sup 137/Cs source, 663 kV) followed by intravenous inoculation of 5.0 x 10/sup 8//kg viable syngeneic bone marrow cells produced transient complete remissions. Repopulation with transplanted marrow was detected along with increasing numbers of recognizable W/Fu AML cells in peripheral blood, marrow, and central nervous system. The delayed leukemia relapse in irradiated transplanted rats compared to irradiated non-transplanted controls suggests an interaction between surviving W/Fu AML cells and transplanted marrow. This model may be of value in studies designing a therapeutic interaction against AML by donor marrow in the chemotherapy, immunotherapy, and total body irradiated patient.

• OSTI ID: 7025358
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 4:5/6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW CELLS
TRANSPLANTS
IMMUNE REACTIONS
BIOLOGICAL RADIATION EFFECTS
IMMUNOSUPPRESSION
RADIOINDUCTION
IMMUNOTHERAPY
MYELOID LEUKEMIA
BIOLOGICAL MODELS
CESIUM 137
COMPARATIVE EVALUATIONS
ENDOXAN
GAMMA RADIATION
LETHAL IRRADIATION
RATS
WHOLE-BODY IRRADIATION
ALKALI METAL ISOTOPES
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CESIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
HEMIC DISEASES
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LEUKEMIA
MAMMALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
THERAPY
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals