Effect of heterologous DNA on repair processes in the mucosa of the rat and mouse small intestine in the presence of the intestinal radiation syndrome. [Lethal, whole-body. gamma. irradiation]

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:7025308

Kudryavtsev, V D; Gumenyuk, L I; Tsygankov, A P

The gastrointestinal syndrome develops in most animal species with exposure to total-body radiation in doses of 1000 R or higher, with which, according to some data, no beneficial effect of DNA preparations on animal survival is observed. At the same time, bearing in mind the high capacity of epithelial cells of the intestine for repair of radiation lesions, one would expect that DNA would have a beneficial effect on recovery processes in the intestine, even with superlethal doses of radiation, and that it would thereby alleviate the course of the intestinal radiation syndrome. There is no agreement on this score. According to some data, administration of exogenous DNA to rats exposed to 900 and 1600 R radiation extended life expectancy, caused an increase in number of epithelial cells in the duodenum, and enhanced mitotic activity of cryptal cells. The findings of other authors indicate that there is no beneficial effect or even an adverse effect of DNA on development of the intestinal syndrome. In order to shed more light on this issue, experiments on rats and mice were conducted to investigate the effect of a single dose of exogenous DNA given at different postradiation times on repair processes in the mucosa of the small intestine and life expectancy in the presence of the intestinal syndrome.

• Research Organization: Scientific Research Inst. of Medical Radiology, Obninsk, USSR
• OSTI ID: 7025308
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:1; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CRYPT CELLS
DIGESTIVE SYSTEM
DNA
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
INTESTINES
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
LIFE SPAN
MAMMALS
MICE
MUCOUS MEMBRANES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATION SYNDROME
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RECOVERY
REPAIR
RODENTS
SMALL INTESTINE
SOMATIC CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION