Oxytocin increases extrapancreatic glucagon secretion and glucose production in pancreatectomized dogs
Infusion of oxytocin into normal dogs increases plasma levels of insulin and glucagon and glucose production and uptake. To determine whether infused oxytocin also increases glucagon secretion from extrapancreatic sites, pancreatectomized dogs, off insulin of 18 hr, were infused with oxytocin and plasma glucagon, and glucose production and uptake were measured using the (6-/sup 3/H)glucose primer-infusion technique. The diabetic dogs, in the control period, had elevated plasma glucose and glucagon levels, an increased rate of glucose production, and a relative decrease in glucose uptake (decreased clearance). Infusion of oxytocin (500 ..mu..U/kg/min) caused a rise in plasma glucagon and glucose levels, increased glucose production, and further decreased glucose clearance. it is concluded that oxytocin can stimulate secretion of extrapancreatic glucagon, which contributes to the increased glucose production.
- Research Organization:
- New York Univ. School of Medicine, NY
- OSTI ID:
- 7025192
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Vol. 182:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
GLUCAGON
BIOCHEMICAL REACTION KINETICS
RADIOIMMUNOASSAY
GLUCOSE
BIOSYNTHESIS
OXYTOCIN
BIOLOGICAL EFFECTS
DIABETES MELLITUS
DOGS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ALDEHYDES
ANIMALS
CARBOHYDRATES
DISEASES
ENDOCRINE DISEASES
HEXOSES
HORMONES
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
METABOLIC DISEASES
MONOSACCHARIDES
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PEPTIDES
PITUITARY HORMONES
POLYPEPTIDES
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
REACTION KINETICS
SACCHARIDES
SYNTHESIS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques