Effect of somatostatin on glucose homeostasis in conscious long-fasted dogs

Journal Article · Thu Oct 01 04:00:00 EDT 1987 · American Journal of Physiology; (USA)

OSTI ID:7018851

Stevenson, R W; Steiner, K E; Hendrick, G K; Cherrington, A D ^[1]

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1. Vanderbilt Univ. School of Medicine, Nashville, TN (USA)

The effects of somatostatin plus intraportal insulin and glucagon replacement (pancreatic clamp) on carbohydrate metabolism were studied in conscious dogs fasted for 7 days so that gluconeogenesis was a major contributor to total glucose production. By use of (3-{sup 3}H)glucose, glucose production (R{sub a}) and utilization (R{sub d}) and glucose clearance were assessed before and after implementation of the pancreatic clamp. After an initial control period, somatostatin (0.8 {mu}g{center dot}kg{sup {minus}1}{center dot}min{sup {minus}1}) was infused with intraportal replacement amounts of glucagon and insulin. The insulin infusion rate was varied to maintain euglycemia and then kept constant for 250 min. Plasma glucagon was similar before and during somatostatin infusion, while plasma insulin was lower. Plasma glucose levels remained similar while R{sub a} and R{sub d} and the ratio of glucose clearance to plasma insulin were significantly increased. Net hepatic lactate uptake and ({sup 14}C)alanine plus ({sup 14}C)lactate conversion to ({sup 14}C)glucose increased. In conclusion, somatostatin alters glucose clearance in 7-day fasted dogs, resulting in changes in several indices of carbohydrate metabolism.

• OSTI ID: 7018851
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 253:4; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACETATES
ALANINES
ALDEHYDES
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
BLOOD-PLASMA CLEARANCE
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CLEARANCE
DOGS
GLUCOSE
HEXOSES
HOMEOSTASIS
HYDROGEN COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
SACCHARIDES
SOMATOSTATIN
TRITIUM COMPOUNDS
VERTEBRATES