Search for mutations altering protein charge and/or function in children of atomic bomb survivors: final report

Journal Article · Sun May 01 04:00:00 EDT 1988 · Am. J. Hum. Genet.; (United States)

OSTI ID:7025155

Neel, J V; Satoh, C; Goriki, K; Asakawa, J; Fujita, M; Takahashi, N; Kageoka, T; Hazama, R

A sample of (1) children whose parents had been proximally exposed (i.e., less than 2000 m from the hypocenter) at the time of the atomic bombings of Hiroshima and Nagasaki and (2) a suitable comparison group have been examined for the occurrence of mutations altering the electrophoretic mobility or activity of a series of 30 proteins. The examination of the equivalent of 667,404 locus products in the children of proximally exposed persons yielded three mutations altering electrophoretic mobility; the corresponding figure for the comparison group was three mutations in 466,881 tests. The examination of a subset of 60,529 locus products for loss of enzyme activity in the children of proximally exposed persons yielded one mutation; no mutations were encountered in 61,741 determinations on the children of the comparison group. When these two series are compared, the mutation rate observed in the children of proximally exposed persons is thus 0.60 x 10(-5)/locus/generation, with 95% confidence intervals between 0.2 and 1.5 x 10(-5), and that in the comparison children is 0.64 x 10(-5)/locus/generation, with 95% intervals between 0.1 and 1.9 x 10(-5). The average conjoint gonad doses for the proximally exposed parents are estimated to be 0.437 Gy of gamma radiation and 0.002 Gy of neutron radiation. If a relative biological effectiveness of 20 is assigned to the neutron radiation, the combined total gonad dose for the parents becomes 0.477 Sv. (Organ absorbed doses are expressed in gray (1 Gy = 100 rad); where dose is a mixture of gamma and neutron radiation, it is necessary because of the differing relative biological effectiveness of gamma and neutron radiation to express the combined gamma-neutron gonad exposures in sieverts (1 Sv = 100 rem)).

• Research Organization: Univ. of Michigan Medical School, Ann Arbor (USA)
• OSTI ID: 7025155
• Journal Information: Am. J. Hum. Genet.; (United States), Journal Name: Am. J. Hum. Genet.; (United States) Vol. 42:5; ISSN AJHGA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
A-BOMB SURVIVORS
AGE GROUPS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHILDREN
DOSES
ELECTROMAGNETIC RADIATION
ENZYMES
GAMMA RADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GONADS
HIROSHIMA
HUMAN POPULATIONS
IONIZING RADIATIONS
JAPAN
MUTATIONS
NAGASAKI
POPULATIONS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RBE
REPRODUCTION
TERATOGENESIS