Pulmonary clearance of three aerosolized solutes in oleic acid-induced lung injury

Journal Article · Tue Mar 01 04:00:00 EST 1988 · J. Appl. Physiol.; (United States)

OSTI ID:7024721

Huchon, G J; Montgomery, A B; Lipavsky, A; Hoeffel, J M; Murray, J F

We studied the effects of oleic acid (OA) on pulmonary clearance of three aerosolized radioactive solutes: /sup 99m/Tc-diethylenetriamine pentaacetate (/sup 99m/Tc-DTPA), /sup 67/Ga-desferoxamine (/sup 67/Ga-DFOM), and /sup 111/In-transferrin (/sup 111/In-TF). Either 0.09 ml/kg OA or an equivalent volume of 0.9% NaCl (controls) was administered intravenously to 48 anesthetized, paralyzed dogs. Each animal received one aerosolized solute either 60 min after (protocol A) or 30 min before (protocol B) the infusion of OA or NaCl. In protocol A clearances of all three solutes were similar in OA and control animals. In contrast, in protocol B clearances of all three solutes increased significantly during OA infusion; during the next 60 min clearances of /sup 99m/Tc-DTPA and /sup 67/Ga-DFOM returned to control values but 111In-TF remained increased. We conclude that 1) in OA-induced permeability edema pulmonary clearance of aerosolized solutes is increased when the aerosol is delivered 30 min before but not 60 min after injury, and 2) increased clearance persists only for large molecules, presumably because smaller molecules cross injured epithelium quickly and completely. These phenomena are best explained by a nonhomogeneous distribution of OA-induced injury.

• Research Organization: Universite Rene Descartes, Paris (France)
• OSTI ID: 7024721
• Journal Information: J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 64:3; ISSN JAPYA
• Country of Publication: United States
• Language: English

Related Subjects

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560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETATES
AEROSOLS
AMINES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
DAYS LIVING RADIOISOTOPES
DEFEROXAMINE
DISPERSIONS
DOGS
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EXCRETION
EXTRACELLULAR SPACE
GALLIUM 67
GALLIUM ISOTOPES
GLOBULINS
GLOBULINS-BETA
HOURS LIVING RADIOISOTOPES
INDIUM 111
INDIUM ISOTOPES
INJURIES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
METALLOPROTEINS
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
OXYGEN
PROTEINS
RADIOACTIVE AEROSOLS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
SOLS
SPACE
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOXICITY
TRACER TECHNIQUES
TRANSFERRIN
VERTEBRATES
YEARS LIVING RADIOISOTOPES