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Influence of prostaglandins E/sub 2/ and F/sub 2. cap alpha. / on the zinc transport across rat mid-intestine in vitro

Conference · · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:7024240
; ; ;
Effects of physiological (5.0 ..mu..M) and pharmacological (50 ..mu..M) doses of prostaglandins (PG) E/sub 2/ and F/sub 2..cap alpha../ on the zinc transport rate across rat jejunum mounted on a Ussing Chamber were determined. Zinc transport rate from mucosal to serosal direction was 4.82 +/- 0.81 n moles/hr/cm/sup 2/ whereas the opposite direction was 18.71 +/- 0.96 n moles/hr/cm/sup 2/. When 5.0 ..mu..M or 50 ..mu..M PGE/sub 2/ or PGF/sub 2..cap alpha../ were added into Ringers-Krebs bicarbonate solution containing 3 mM L-histidine and 0.5 mM /sup 65/Zn Cl/sub 2/ to the mucosal side of mucosa, no significant difference in /sup 65/Zn transport rate was observed compared to controls. However, 5.0 ..mu..M PGF/sub 2..cap alpha../ and 50 ..mu..M PGE/sub 2/ significantly inhibited zinc transport from mucosal to serosal direction. When PGs were added to the opposite side of mucosa, only 5.0 ..mu..M PGs significantly inhibited zinc transport from serosal to mucosal direction. Results suggest that PGs act on the inhibition of zinc transport across the basolateral membrane of columnar absorbing cells and that 50 ..mu..M PGE/sub 2/ was the most powerful inhibitor.
Research Organization:
VA Medical Center, Sepulveda, CA
OSTI ID:
7024240
Report Number(s):
CONF-8604222-
Conference Information:
Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:4
Country of Publication:
United States
Language:
English

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Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
IN VITRO
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
MEMBRANE TRANSPORT
METABOLISM
METALS
NUCLEI
ORGANS
PROSTAGLANDINS
RADIOISOTOPES
SMALL INTESTINE
TRACER TECHNIQUES
ZINC
ZINC 65
ZINC ISOTOPES