Synthesis of C-2 and C-4 deuterium-labeled estradiol-17 beta
Journal Article
·
· Steroids; (United States)
Estradiol-17 beta labeled with deuterium in the positions 2 or 4 can be prepared from 2-chloromercurio-1,3,5(10)-estratriene-3,17 beta-diol 3-methyl ether 17-acetate or 4-chloromercurio-1,3,5(10)-estratriene-3,17 beta-diol, respectively, in refluxing CH3COO(2)H/(2)H2O. The same reaction performed on 4-acetoxymercurio-1,3,5(10)-estratriene-3,17 beta-diol afforded 2,4-dideuterio-estradiol-17 beta in good yields.
- Research Organization:
- Universita di Milano, Italy
- OSTI ID:
- 7023203
- Journal Information:
- Steroids; (United States), Journal Name: Steroids; (United States) Vol. 41:6; ISSN STEDA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Synthesis and evaluation of (17 alpha,20E)-21-(/sup 125/I)iodo-19-norpregna-1,3,5(10),20-tetraene-3,17 -diol and (17 alpha,20E)-21-(/sup 125/I)iodo-11 beta-methoxy-19-norpregna-1,3,5(10),20-tetraene-3,17-diol (17 alpha-(iodovinyl)estradiol derivatives) as high specific activity potential radiopharmaceuticals
Human placental estradiol 17. beta. -dehydrogenase: evidence for inverted substrate orientation (wrong-way binding) at the active site
Direct radioimmunoassay of 17. beta. -estradiol in ether extracts of bovine
Journal Article
·
Mon Oct 01 00:00:00 EDT 1984
· J. Med. Chem.; (United States)
·
OSTI ID:5974365
Human placental estradiol 17. beta. -dehydrogenase: evidence for inverted substrate orientation (wrong-way binding) at the active site
Journal Article
·
Tue Jun 14 00:00:00 EDT 1988
· Biochemistry; (United States)
·
OSTI ID:6998231
Direct radioimmunoassay of 17. beta. -estradiol in ether extracts of bovine
Journal Article
·
· J. Agric. Food Chem.; (United States)
·
OSTI ID:6704762
Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
CHEMICAL PREPARATION
CHEMICAL REACTIONS
CHEMISTRY
DEUTERATION
DEUTERIUM COMPOUNDS
ESTRADIOL
ESTRANES
ESTROGENS
HORMONES
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
LABELLING
ORGANIC COMPOUNDS
RADIOCHEMISTRY
STEROID HORMONES
STEROIDS
SYNTHESIS
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
CHEMICAL PREPARATION
CHEMICAL REACTIONS
CHEMISTRY
DEUTERATION
DEUTERIUM COMPOUNDS
ESTRADIOL
ESTRANES
ESTROGENS
HORMONES
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
LABELLING
ORGANIC COMPOUNDS
RADIOCHEMISTRY
STEROID HORMONES
STEROIDS
SYNTHESIS