Changes in the radiation sensitivity of mouse skin during fractionated and prolonged treatments

Journal Article · Thu Sep 01 04:00:00 EDT 1994 · Radiation Research

DOI:https://doi.org/10.2307/3578831· OSTI ID:70221

Ruifrok, A C.C.; Mason, K A; Hunter, N; Thames, H D ^[1]

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1. Univ. of Texas M.D. Anderson Cancer, Houston, TX (United States)

Reactions of the skin of the right thigh of mice were used as an experimental model to test possible changes in the radiosensitivity of mouse skin, as represented by changes in the linear-quadratic (LQ) model parameters {alpha} and {beta}, as a function of fractionation interval and overall treatment time. In the first series of experiments, variable numbers of 3-Gy fractions with intervals of 6, 24 or 48 h were applied, followed by top-up doses to increase the skin damage to a level that could be scored. The results showed that mouse skin is more sensitive to 3-Gy fractions applied with 48-h intervals than to 3-Gy fractions applied with 6- or 24-h intervals. In the second series of experiments we used single-dose or fractonated test treatments for previously unirradiated mice and mice treated with priming doses of 10, 20 or 30 Gy given 1-18 days before the test treatment. The sensitivity appeared to be higher after intervals of 14-18 days than after 1-10 days after priming treatments of 20 and 30 Gy. The increased sensitivity 18 days after 20 Gy was mainly the result of an increase in the {beta} component of the LQ model; higher values of {alpha} were also determined. We conclude that the radiosensitivity of mouse skin is higher during a radiation-induced proliferative response. 28 refs., 3 figs., 7 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 70221
• Journal Information: Radiation Research, Journal Name: Radiation Research Journal Issue: 3 Vol. 139; ISSN RAREAE; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
FRACTIONATED IRRADIATION
MICE
RADIOSENSITIVITY
SKIN
TIME DEPENDENCE