Responses to graded phytic acid in young Japanese quail

Conference · Wed Mar 05 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:7022021

Fox, M R.S.; Tao, S H; Fry, Jr, B E; Phillippy, B Q; Lee, Y H; Johnston, M R

Graded levels of phytic acid (PA) were fed to day-old Japanese quail (Coturnix coturnix japonica) for 7 d to establish responses for evaluating effects of inositol tri-, tetra-, and pentaphosphates. Sodium phytate was added to supply 1.4, 2.8, 5.5, 8.4, 11.0, and 13.8 g PA/kg adequate casein-gelatin diet containing 20 mg Zn/kg. Eleven g phytic acid approximates that in diets containing defatted soy flour as the protein source. PA:Zn molar ratios were 7, 14, 27, 41, 54, and 68. The effects and graded response ranges (g PA/kg diet) were as follows: decreased body weight, 2.8-13.8; defective feathering, 1.4-5.5; decreased tibia Zn, 1.4-5.5; decreased tibia ash, 1.4-13.8; and decreased pancreas Zn, 1.4-5.5. The lowest level of PA produced marked decreases in tibia and pancreas Zn; thus the PA ranges can be extended to even lower levels. The effects of PA were reproducible between experiments and the mean values were reproducible except for tibia ash and liver Mn, which varied somewhat. There were no effects of PA on liver Zn and Mg, or on pancreas Fe and Mg; the effects on liver Fe and Cu, and tibia Fe and Mg were small and inconsistent. The responses to PA and the dose ranges provide a realistic basis for assessing the biological effects of other inositol phosphates that can be formed during food processing.

• Research Organization: Federal Drug Administration, Washington, DC
• OSTI ID: 7022021
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:4
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BIOLOGICAL AVAILABILITY
BIOLOGICAL EFFECTS
BIRDS
COPPER
DISTRIBUTION
ELEMENTS
ESTERS
IRON
MAGNESIUM
METABOLISM
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHORIC ACID ESTERS
PHYTIC ACID
TISSUE DISTRIBUTION
TRANSITION ELEMENTS
VERTEBRATES
ZINC