Final report on the peri-/postnatal evaluation of hexachloro-1,3-butadiene (HCBD) toxicity in Cd rats. Report for 27 February 1988-3 April 1989

Technical Report · Wed May 23 04:00:00 EDT 1990

OSTI ID:7019448

Field, E A; Sleet, R B; Price, C J; Marr, M C; Myers, C B

Hexachloro-1,3-butadiene (HCBD) is an agricultural and industrial chemical and by-product which has been identified as a neprhotoxin in both humans and laboratory animals. It is used industrially to recover chlorine-containing gas, as a fluid for gyroscopes and in the production of lubricants and rubber. HCBD is also a by-product of chlorinated hydrocarbon production. Agriculturally, it is used as a fumigant on grapes. HCBD contamination has been detected in air, water and soil surrounding chemical manufacturing plants and toxic waste landfills and in food and beverages. The current study was undertaken to examine peri-/postnatal development of the rat during maternal exposure to HCBD in the diet during late gestation and lactation with particular attention to structural and functional renal endpoints.

• Research Organization: Research Triangle Inst., Durham, NC (United States)
• OSTI ID: 7019448
• Report Number(s): PB-93-123867/XAB; RTI--243; CNN: NIEHS-N01-ES-55080
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BUTADIENE
BY-PRODUCTS
CHEMICAL ANALYSIS
COMMERCIAL SECTOR
DIENES
EVALUATION
HYDROCARBONS
LABORATORY ANIMALS
MAMMALS
ORGANIC COMPOUNDS
POLYENES
RATS
RODENTS
SOILS
TOXICITY
VERTEBRATES