Activation of brain mitochondrial Ca sup 2+ uptake by polyamines and by Ca sup 2+

Thesis/Dissertation · Fri Jan 01 00:00:00 EST 1988

OSTI ID:7018870

Jensen, J R

The activation of mitochondrial Ca{sup 2+} uptake by Ca{sup 2+}, and by the endogenous polyamines, spermine and spermidine, was investigated in regard to both the mechanism of activation, and to the developmental changes and brain regional differences of these effects. Ca{sup 2+} uptake by isolated brain mitochondria was characterized by analysis of {sup 45}Ca{sup 2+} uptake and by use of a Ca{sup 2+}-selective electrode. A novel Ca{sup 2+} loading procedure was used to estimate steady-state rates of uptake, and the results were compared to the initial rates of {sup 45}Ca{sup 2+} uptake.

• Research Organization: California Univ., Irvine, CA (USA)
• OSTI ID: 7018870
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AMINES
BIOCHEMICAL REACTION KINETICS
CALCIUM COMPOUNDS
MEMBRANE TRANSPORT
BRAIN
CALCIUM 45
CATIONS
MITOCHONDRIA
SPERMIDINE
SPERMINE
STEADY-STATE CONDITIONS
TRACER TECHNIQUES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALCIUM ISOTOPES
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
IONS
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
RADIOISOTOPES
REACTION KINETICS
550201* - Biochemistry- Tracer Techniques