Modeling the accumulation of three waterborne chlorinated ethanes in fathead minnows (Pimephales promelas): A physiologically based approach
- Environmental Protection Agency, Duluth, MN (United States). Environmental Research Lab.
- AScI Corp., Inc., Duluth, MN (United States)
A physiologically based kinetic model was used to predict the accumulation of a homologous series of chlorinated ethanes in fathead minnows (Pimephales promelas). Uptake and accumulation of these compounds are described in terms of a few fundamental physiological, morphological, and physicochemical parameters. Chemical residues in 30-d-old fathead minnows exposed to 1,1,2,2-tetrachloroethane, pentachloroethane, and hexachloroethane were used to evaluate model performance. The predicted and observed accumulations of the chlorinated ethanes were in close agreement. A quantitative assessment of the major factors regulating the exchanged of these compounds indicates that the cutaneous surface may be an important route of uptake in small fish.
- OSTI ID:
- 7017017
- Journal Information:
- Environmental Toxicology and Chemistry; (United States), Journal Name: Environmental Toxicology and Chemistry; (United States) Vol. 13:7; ISSN 0730-7268; ISSN ETOCDK
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
540320* -- Environment
Aquatic-- Chemicals Monitoring & Transport-- (1990-)
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL ACCUMULATION
BIOLOGICAL INDICATORS
CHLORINATED ALIPHATIC HYDROCARBONS
FATHEAD MINNOW
FISHES
HALOGENATED ALIPHATIC HYDROCARBONS
MATHEMATICAL MODELS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
POLLUTION
SENSITIVITY
VERTEBRATES
WATER POLLUTION