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Modeling the accumulation of three waterborne chlorinated ethanes in fathead minnows ( pimephales promelas'): A physiologically based approach

Technical Report ·
OSTI ID:6838179
; ; ;
A physiologically based kinetic model was used to predict the accumulation of a homologous series of chlorinated ethanes in fathead minnows (Pimephales promelas). Uptake and accumulation of these compounds are described in terms of a few fundamental physiological, morphological, and physicochemical parameters. Chemical residues in 30-d-old fathead minnows exposed to 1,1,2,2-tetrachloroethane, pentachloroethane, and hexachloroethane were used to evaluate model performance. The predicted and observed accumulations of the chlorinated ethanes were in close agreement. A quantitative assessment of the major factors regulating the exchange of these compounds indicates that the cutaneous surface may be an important route of uptake in small fish.
Research Organization:
Environmental Protection Agency, Duluth, MN (United States). Environmental Research Lab.
OSTI ID:
6838179
Report Number(s):
PB-94-210416/XAB; EPA--600/J-94/354
Country of Publication:
United States
Language:
English

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Related Subjects

54 ENVIRONMENTAL SCIENCES
540320 -- Environment
Aquatic-- Chemicals Monitoring & Transport-- (1990-)
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKANES
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL ACCUMULATION
CHLORINATED AROMATIC HYDROCARBONS
ETHANE
FATHEAD MINNOW
FISHES
HALOGENATED AROMATIC HYDROCARBONS
HYDROCARBONS
KINETICS
MATHEMATICAL MODELS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
REACTION KINETICS
UPTAKE
VERTEBRATES